Sequence segregation improves non-covalent protein delivery
نویسندگان
چکیده
منابع مشابه
Sequence segregation improves non-covalent protein delivery.
The impermeability of the plasma membrane towards large, hydrophilic biomolecules is a major obstacle in their use and development against intracellular targets. To overcome such limitations, protein transduction domains (PTDs) have been used as protein carriers, however they often require covalent fusion to the protein for efficient delivery. In an effort to develop more efficient and versatil...
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The major obstacle to clinical development of siRNAs (short interfering RNAs), like for most of the nucleic-acid-based strategies, is their poor cellular uptake and bioavailability. Although several viral and non-viral strategies have been proposed to improve siRNA delivery, their applications in vivo remain a major challenge. We have developed a new strategy, based on a short amphipathic pepti...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2017
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2017.03.387